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Dr. Ayad


Research Interests








Contact Information:


The Miami Project
to Cure Paralysis


1095 NW 14th Terrace


Locator Code R-48


Miami, Florida 33136



Tel:  (305) 243-7695


Home > Our Research Faculty > Nagi Ayad, Ph.D..




Associate Professor, Department of Psychiatry and Behavioral Sciences 

Cell Cycle Transitions in the Developing and Diseased Nervous Systems



Research Interests

The research in my laboratory focuses on cell cycle transitions in the developing nervous system.  My laboratory identified essential proteins required for controlling mitotic entry and exit and also demonstrated that cell cycle proteins are present and active in the developing nervous system and fully differentiated neurons.  Specifically, the research group uncovered the mechanism through which the Anaphase Promoting Complex/Cyclosome (APC/C) and other cell cycle regulators such as Wee 1 control cell proliferation, cycle exit, and differentiation.  These neural progenitor cell cycle proteins are kinases, ubiquitin ligases, and epigenetic enzymes that may be targets in cancer, spinal cord injury, and traumatic brain injury.  Thus, my laboratory is searching for novel molecular pathways that control neural development and are targets in multiple human maladies.  This is accomplished using a multi-disciplinary approach that utilizes whole genome, siRNA, cDNA, and small molecule cell-based screens to develop therapies.


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