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Dr. Ayad


 

Research Interests

 

Affiliations 

  

Publications

 

CV

 


Contact Information:


 

The Miami Project
to Cure Paralysis

 

1095 NW 14th Terrace

 

Locator Code R-48

 

Miami, Florida 33136

 

 

Tel:  (305) 243-7695

 

 

NAyad@miami.edu

 

Home > Our Research Faculty > Nagi Ayad, Ph.D..

 

 

NAGI AYAD, PH.D.

Associate Professor, Department of Psychiatry and Behavioral Sciences 

Cell Cycle Transitions in the Developing and Diseased Nervous Systems

 

 

Research Interests


The research in my laboratory focuses on cell cycle transitions in the developing nervous system.  My laboratory identified essential proteins required for controlling mitotic entry and exit and also demonstrated that cell cycle proteins are present and active in the developing nervous system and fully differentiated neurons.  Specifically, the research group uncovered the mechanism through which the Anaphase Promoting Complex/Cyclosome (APC/C) and other cell cycle regulators such as Wee 1 control cell proliferation, cycle exit, and differentiation.  These neural progenitor cell cycle proteins are kinases, ubiquitin ligases, and epigenetic enzymes that may be targets in cancer, spinal cord injury, and traumatic brain injury.  Thus, my laboratory is searching for novel molecular pathways that control neural development and are targets in multiple human maladies.  This is accomplished using a multi-disciplinary approach that utilizes whole genome, siRNA, cDNA, and small molecule cell-based screens to develop therapies.
 

 

 
 
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