Google +
 
   
 

Dr. Ghosh


 

Research Interests


 

Affiliations

 


Publications

 

CV 
 


Contact Information:


 

The Miami Project
to Cure Paralysis

 

1095 NW 14th Terrace

 

Locator Code R-48

 

Miami, Florida 33136

 

 

Tel:  (305) 243-6001

 

 

mghosh@med.miami.edu

 

 

 

Home > Our Research Faculty > Mousumi Ghosh, Ph.D.

 

MOUSUMI GHOSH, PH.D.

Research Assistant Professor, Department of Neurological Surgery

Altering Host Glial Responses following CNS Injury and Disease to Promote Repair

 

 

Research Interests


My laboratory’s research interests are focused on altering the hostile environment of the injured or diseased CNS to one that is conducive to repair through altering inflammation. Specifically our work focuses on delineating the intrinsic and extrinsic signals present after injury that antagonize the conversion of activated microglia and macrophages to a reparative M2 phenotype in experimental models of CNS injury and disease, such as Multiple Sclerosis. By understanding the signals that govern macrophage-microglia phenotype, we aim to develop novel, molecular and immuno-pharmacological therapeutic strategies to promote M1 (cytotoxic) to M2 (reparative) conversion of these cells to induce neuroprotection, neuroplasticity and/or disease remission. We are also interested in understanding how altering the immunophenotypical profile of macrophages and microglia can affect host glial responses, including glial scar formation, as well as influence the ability of transplanted cells, such as Schwann cells and stem cells, to mediate neurorepair.

 

   

Harnessing the Immune Response after CNS Injury or Disease to Promote Repair
 
M1-M2 MACROPHAGES
AND MICROGLIA
HOST GLIAL CELL RESPONSES      CELL THERAPIES
Microglia  Host Glial Responses  Cell Therapies
Understanding the signaling pathways involved in classical and alternative activation of microglia/macrophages Inducing an environment for repair in the injured/diseased CNS by immunomodulation Altering host immune responses to improve the neurorepair provided by cell therapies

 

 

 

 

 
 
Copyright 2014 University of Miami. All rights reserved.